A lesson from the past: Lobotomising

the prefrontal cortex

Your knowledge of a lobotomy may be based on Jack Nicolson’s excellent portrayal

of a rebellious patient at a mental hospital in the film One Flew Over the Cuckoo’s

Nest. According to the other patients in the hospital, a lobotomy effectively reduced

someone to the same mental state as a shop window mannequin – expressionless

and unemotional.

The lobotomy procedure consists of cutting the brain connections that go in and

out of the prefrontal cortex (see ‘Keeping the brain alert and active’ for informa-

tion on the prefrontal cortex). Doctors considered a lobotomy the final step for

modifying extreme behaviour when other treatments, such as shock therapy or

electrical shock treatment, failed to change a patient’s behaviour. Doctors thought

that a lobotomy calmed the patient, reduced aggressive behaviour, and improved

the patient’s quality of life. However, scientists now know that this procedure is no

longer necessary.

Perhaps one of the youngest known recipients of a lobotomy is Howard Dully, who

was only 12 years old at the time. As a result of a diagnosis of childhood schizo-

phrenia (that was unconfirmed by other medical professionals at the time), Howard

underwent the procedure. His mental illness manifested itself in some ways as a

typical teenager – he was moody, insolent, and contrary. However, the truth behind

his behaviour was harder to decipher – what was Dully really like and was his

behaviour so extreme that a lobotomy was the only option? These questions have

spawned Dully’s lifelong search for answers.

He took several decades to recover, drifting from a mental institute, to prison, and

finally to the streets. He’s since overcome his setbacks and recounted his story in a

harrowing tale of survival and redemption from a brutal procedure once considered

acceptable by doctors but, thankfully, no longer in practice today.

Dully’s story is interesting because it reveals that our knowledge of the brain is

evolving. His journey has also served to fuel many heated discussions about how

the brain works and the impact of removing sections of the brain.

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